In our latest work published in Biomedical Optics Express, Giovani Martins et al. demonstrate that noninvasive diffuse optical techniques can reliably measure brain physiology in children with sickle cell anemia at the bedside. Across different operators and repeated measurements for the same operator, parameters such as cerebral blood flow were consistent and reproducible. These results support the use of optical techniques as tools for routine monitoring of brain health and for tracking treatment-related changes in this population.