In the Buckley Lab’s latest publication in Biomedical Optics Express, Giovani Martins et al. demonstrates that cerebral blood flow measured by Diffuse Correlation Spectroscopy, a portable, noninvasive light-based technique, correlates with transcranial Doppler ultrasound measurements in children with sickle cell disease – the standard clinical method to screen stroke risk in these patients. These results suggest that Diffuse Correlation Spectroscopy is able monitor brain health at the bedside in this population.