New paper out establishing the feasibility and reliability of broadband absorption spectroscopy for measuring cerebral water content in adults

In the Buckley Lab’s latest publication in Biomedical Optics Express, Vidisha Goyal et al. demonstrate the reliability of Broadband Absorption Spectroscopy (BAS) to measure water content in the adult human head in a variety of different environments. To date, BAS estimates of water have primarily been focused on in vitro validation studies and in vivo breast cancer applications. Recent work has demonstrated that BAS may be sensitive to brain water content in a pig model. While initial studies are promising, BAS has yet to be used to quantify brain water content in the adult human head. In this work, we take the first steps towards demonstrating the feasibility of BAS to reliably measure water content in the adult human head. Demonstrating that BAS can deliver reproducible measurements is crucial for its adoption in both research and clinical settings. Our results suggest the approach is feasible and repeatable, and lay the groundwork for future studies that establish the sensitivity of BAS to cerebral edema.