Buckley Lab awarded NIH R01 to investigate vascular function after mild traumatic brain injury

Dr. Buckley was recently awarded an R01 from the NINDS to study the role of p38 MAPK signaling in neurons after repetitive mild traumatic brain injury. This multi-disciplenary work will be performed with co-PI Dr. Levi Wood (Georgia Tech, Mechanical Engineering). It is well known that repetitive mild traumatic brain injuries (rmTBIs) can lead to long-term cognitive changes, neurodegeneration, and dementia. However, the mechanisms responsible for the long-term effects of repetitive mTBI are poorly understood and effective therapeutic strategies are lacking. This proposal will use a physiologically relevant mouse model of repetitive mTBI to determine if stress response in neurons is responsible for triggering neuroinflammation, loss of cognitive function, and reduction in brain blood flow.