DoD Grant Awarded to study biomarkers and mechanisms in repetitive concussion

In May, Drs. Buckley and Wood were awarded a Co-PI Peer Reviewed Alzheimer’s Research Program grant from the Department of Defense to 1) investigate acute hemodynamic and metabolic biomarkers of long-term pathological changes (i.e., amyloid beta and tau tangles) after repetitive sports-related head injury, and 2) understand inflammatory mechanisms driving changes in these acute biomarkers. Promising biomarkers found in this proposal can be readily translated to controlled clinical studies, as many of the parameters we are studying can be quantified non-invasively in the emergency room, battlefield, or sideline setting. Further, successful drug treatments found in our mechanistic evaluation could represent easily translatable therapies to test in patient studies, as some of the drugs we are testing are already approved for clinical use by the FDA.